产品货号：
GS4380
中文名称：
重组人sCD40 Ligand
英文名称：
Recombinant Human soluble CD40 Ligand
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 16.3kDa,a single non-glycosylated polypeptide chain containing 149 amino acids.
储存条件：冷冻（-20℃）
概述
CD40 ligand is a 261 amino acid type II transmembrane glycoprotein belonging to the TNF family and can be cleaved into two chains:the CD40 ligand membrane form and CD40 ligand soluble form.It is primarily expressed on activated CD4+ T lymphocytes,and also found in other types of cells,like NK cells,mast cells,basophils and eosinophils.In total CD40 ligand has three binding partners:CD40,α5β1 integrin and αIIbβ3.It mediates a range of activities on B cells including induction of activation-associated surface antigen,entry into cell cycle,isotype switching and Ig secretion and memory generation.CD40-CD40Linteraction also plays important roles in monocyte activation and dendritic cell maturation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人sCD40 Ligand，sCD40 Ligand, Human，Recombinant Human soluble CD40 Ligand
储存条件：冷冻（-20℃）
概述
CD40 ligand is a 261 amino acid type II transmembrane glycoprotein belonging to the TNF family and can be cleaved into two chains:the CD40 ligand membrane form and CD40 ligand soluble form.It is primarily expressed on activated CD4+ T lymphocytes,and also found in other types of cells,like NK cells,mast cells,basophils and eosinophils.In total CD40 ligand has three binding partners:CD40,α5β1 integrin and αIIbβ3.It mediates a range of activities on B cells including induction of activation-associated surface antigen,entry into cell cycle,isotype switching and Ig secretion and memory generation.CD40-CD40Linteraction also plays important roles in monocyte activation and dendritic cell maturation.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC is less than 5-10ng/ml. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.0. |
| 内毒素 | Less than 1 EU/μg of rHusCD40Las determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL |
相关搜索：重组人sCD40 Ligand，sCD40 Ligand, Human，Recombinant Human soluble CD40 Ligand